Table 2 Univariate analysis to identify risk factors associated with the recurrence of HCC patients with staging I–II
Variables | Statistics | HR 95%CI | P Value |
|---|---|---|---|
Age (years) | |||
≤ 60 | 351 (70.766%) | 1.0 | |
> 60 | 145 (29.234%) | 0.742 (0.540, 1.020) | 0.06634 |
Sex | |||
Male | 394 (79.435%) | 1.0 | |
Female | 102 (20.565%) | 0.638 (0.435, 0.937) | 0.02180 |
Smoking | |||
No | 316 (63.710%) | 1.0 | |
Yes | 180 (36.290%) | 1.346 (1.016, 1.783) | 0.03872 |
Drinking | |||
No | 387 (78.024%) | 1.0 | |
Yes | 109 (21.976%) | 1.208 (0.878, 1.662) | 0.24598 |
HCC family history | |||
No | 436 (87.903%) | 1.0 | |
Yes | 60 (12.097%) | 1.248 (0.837, 1.861) | 0.27741 |
HBsAg | |||
Negative | 71 (14.609%) | 1.0 | |
Positive | 415 (85.391%) | 1.627 (1.024, 2.583) | 0.03917 |
ALT (U/L) | 30.00 (8.00–605.00) | 1.002 (0.999, 1.004) | 0.20455 |
AST (U/L) | 30.00 (12.00–386.00) | 1.005 (1.001, 1.008) | 0.00610 |
ALP (U/L) | 93.767 ± 47.817 | 1.006 (1.004, 1.009) | < 0.00001 |
GLR | 30.61 (3.00–636.84) | 1.003 (1.002, 1.004) | < 0.00001 |
HB (g/L) | 133.773 ± 17.953 | 1.011 (1.003, 1.019) | 0.01016 |
PLT (10^9/L) | 137.879 ± 61.046 | 1.001 (0.998, 1.003) | 0.62340 |
AFP (ng/ml) | |||
≤ 20 | 214 (45.053%) | 1.0 | |
> 20 | 261 (54.947%) | 1.605 (1.199, 2.150) | 0.00149 |
Child–Pugh class | |||
A | 472 (95.161%) | 1.0 | |
B | 24 (4.839%) | 1.050 (0.572, 1.930) | 0.87432 |
Differentiation | |||
Well-moderate | 426 (89.684%) | 1.0 | |
Poor | 49 (10.316%) | 0.932 (0.586, 1.484) | 0.76792 |
Lymphovascular invasion | |||
No | 392 (79.032%) | 1.0 | |
Yes | 104 (20.968%) | 2.337 (1.705, 3.204) | < 0.00001 |
ASA | |||
I | 51 (10.324%) | 1.0 | |
II | 408 (82.591%) | 1.007 (0.638, 1.587) | 0.97718 |
III | 35 (7.085%) | 0.947 (0.482, 1.864) | 0.87588 |
Operation time (min) | 161.371 ± 58.525 | 1.002 (1.000, 1.005) | 0.03542 |
Urine volume (ml) | 300.00(0.00–2150.00) | 1.000 (1.000, 1.001) | 0.39094 |
Blooding volume (ml) | 300.00 (5.00–5000.00) | 1.000 (1.000, 1.000) | 0.18443 |
Allogeneic blood | |||
No | 424 (86.004%) | 1.0 | |
Yes | 69 (13.996%) | 1.542 (1.070, 2.223) | 0.02024 |
Tumor number | |||
Single | 465 (93.750%) | 1.0 | |
Mutiple | 31 (6.250%) | 1.885 (1.127, 3.150) | 0.01565 |
TNM | |||
I | 364 (73.387%) | 1.0 | |
II | 132 (26.613%) | 2.443 (1.813, 3.292) | < 0.00001 |
Tumor size (cm) | |||
≤ 5 | 332 (66.935%) | 1.0 | |
> 5 | 164 (33.065%) | 1.633 (1.229, 2.170) | 0.00071 |