Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia

Table 3 Regression coefficients and standard errors (SE) for the association between high risk and low risk HPV infections and DMR methylation

Regulatory DMR	All, N = 419 Coefficients (SE)		Blacks, N = 168 Coefficients (SE)		Whites, N = 206 Coefficients (SE)
	HR-HPV	LR-HPV	HR-HPV	LR-HPV	HR-HPV	LR HPV
PEG3	−0.30 (0.77), p = .69	1.44 (0.90), p = .11	0.04 (1.21), p = .97	2.51 (1.47), p = .09)	No convergence	−1.21 (1.29), p = .35
PLAGL1/HYMAI	−2.85 (0.92), p < .01	−1.55 (1.08), p = .15	−2.68 (1.34), p = .04	−1.50 (1.68), p = .37	−1.95 (1.39), p = .16	−0.58 (1.60), p = .71
Kv DMR	0.37 (0.50), p = .47	0.33 (0.59), p = .58	1.80 (0.81), p = .03	2.51 (0.96), p < .01	−0.87 (0.74), p = .24	−1.39 (0.86), p = .11
IGF2/H19	2.49 (1.37), p = .07	2.80 (1.58), p = .08	3.02 (2.27), p = .18	3.11 (2.73), p = .25	2.84 (1.92), p = .14	2.84 (2.18), p = .19
IGF2AS	1.91 (1.35), p = .16	1.91 (1.56), p = .22	1.27 (2.13), p = .55	0.82 (2.54), p = .75	1.86 (1.98), p = .34	2.49 (2.22), p = .26
MESTIT1/MEST	1.46 (0.83), p = .08	0.95 (0.96), p = .33	−0.94 (1.37), p = .49	−1.55 (1.60), p = .33	2.23 (1.20), p = .06	1.68 (1.39), p = .23
PEG10	0.84 (0.50), p = .09	2.00 (0.59), p < .01	0.83 (0.78), p = .28	1.35 (0.94), p = .14	0.72 (0.75), p = .33	2.05 (0.85), p = .01
MEG3	−0.17 (1.17), p = .88	−2.08 (1.41) p = .14	−0.17 (1.17), p = .89	−2.08 (1.41), p = .14	3.82 (1.04), p < .01	3.25 (1.17), p < .01

Abbreviations: DMR Differentially methylated regions. HR-HPV High-risk human papillomavirus, LR-HPV Low-risk human papillomavirus, SE Standard error
Mixed models allowed for adjustment of individual CpGs at each DMR
No HPV infection served as the referent category

ISSN: 1750-9378