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Table 3 Regression coefficients and standard errors (SE) for the association between high risk and low risk HPV infections and DMR methylation

From: Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia

Regulatory DMR All, N = 419
Coefficients (SE)
Blacks, N = 168
Coefficients (SE)
Whites, N = 206
Coefficients (SE)
  HR-HPV LR-HPV HR-HPV LR-HPV HR-HPV LR HPV
PEG3 −0.30 (0.77), p = .69 1.44 (0.90), p = .11 0.04 (1.21), p = .97 2.51 (1.47), p = .09) No convergence −1.21 (1.29), p = .35
PLAGL1/HYMAI −2.85 (0.92), p < .01 −1.55 (1.08), p = .15 2.68 (1.34), p = .04 −1.50 (1.68), p = .37 −1.95 (1.39), p = .16 −0.58 (1.60), p = .71
Kv DMR 0.37 (0.50), p = .47 0.33 (0.59), p = .58 1.80 (0.81), p = .03 2.51 (0.96), p < .01 −0.87 (0.74), p = .24 −1.39 (0.86), p = .11
IGF2/H19 2.49 (1.37), p = .07 2.80 (1.58), p = .08 3.02 (2.27), p = .18 3.11 (2.73), p = .25 2.84 (1.92), p = .14 2.84 (2.18), p = .19
IGF2AS 1.91 (1.35), p = .16 1.91 (1.56), p = .22 1.27 (2.13), p = .55 0.82 (2.54), p = .75 1.86 (1.98), p = .34 2.49 (2.22), p = .26
MESTIT1/MEST 1.46 (0.83), p = .08 0.95 (0.96), p = .33 −0.94 (1.37), p = .49 −1.55 (1.60), p = .33 2.23 (1.20), p = .06 1.68 (1.39), p = .23
PEG10 0.84 (0.50), p = .09 2.00 (0.59), p < .01 0.83 (0.78), p = .28 1.35 (0.94), p = .14 0.72 (0.75), p = .33 2.05 (0.85), p = .01
MEG3 −0.17 (1.17), p = .88 −2.08 (1.41) p = .14 −0.17 (1.17), p = .89 −2.08 (1.41), p = .14 3.82 (1.04), p < .01 3.25 (1.17), p < .01
  1. Abbreviations: DMR Differentially methylated regions. HR-HPV High-risk human papillomavirus, LR-HPV Low-risk human papillomavirus, SE Standard error
  2. Mixed models allowed for adjustment of individual CpGs at each DMR
  3. No HPV infection served as the referent category