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Table 2 Odds ratios (OR) and 95% confidence intervals (CI) for associations between methylation levels of differentially methylated regions (DMR) regulating genomically imprinted genes and CIN

From: Association between PEG3 DNA methylation and high-grade cervical intraepithelial neoplasia

  All, N = 419
ORa (95% CI)
Black, N = 168
ORa (95% CI)
White, N = 206
ORa (95% CI)
Regulatory DMR CIN2+ vs. ≤CIN1 CIN3+ vs. ≤CIN2 CIN2+ vs. ≤CIN1 CIN3+ vs. ≤CIN2 CIN2+ vs. ≤ CIN1 CIN3+ vs. ≤ CIN2
PEG3 1.16 (0.87–1.56) 0.79 (0.48–1.31) 1.31 (0.76–2.25) 1.71 (0.71–4.10) 1.13 (0.73–1.75) 0.70 (0.37–1.32)
PLAGL1/HYMAI 1.01 (0.73–1.38) 0.92 (0.51–1.66) 0.82 (0.44–1.52) 1.15 (0.51–2.58) 0.98 (0.63–1.52) 0.75 (0.35–1.61)
Kv DMR 1.21 (0.80–1.83) 0.91 (0.43–1.89) 1.22 (0.68–2.17) 1.47 (0.67–3.21) 1.58 (0.74–3.35) 0.88 (0.32–2.26)
IGF2/H19 1.15 (0.72–1.82) 0.76 (0.41–1.42) 0.43 (0.17–1.06) 0.43 (0.14–1.31) 1.61 (0.85–3.06) 0.93 (0.44–2.00)
IGF2AS 1.13 (0.93–1.38) 1.16 (0.82–1.65) 1.20 (0.85–1.71) 1.22 (0.73–2.03) 1.12 (0.85–1.48) 1.08 (0.72–1.61)
MESTIT1/MEST 1.08 (0.74–1.58) 0.90 (0.48–1.70) 1.14 (0.59–2.20) 0.36 (0.13–1.98) 0.88 (0.52–1.47) 1.11 (0.51–2.42)
PEG10 1.15 (0.73–1.81) 1.04 (0.48–2.23) 1.25 (0.50–3.13) 1.73 (0.45–6.74) 1.00 (0.54–1.85) 0.82 (0.32–2.08)
MEG3 1.01 (0.79–1.28) 1.38 (0.95–1.99) 0.95 (0.63–1.44) 1.06 (0.60–1.88) 1.13 (0.80–1.62) 1.58 (0.97–2.58)
  1. Abbreviations: CIN Cervical intraepithelial neoplasia, DMR Differentially methylated region, OR Odds ratio
  2. aOR adjusted for age, high risk HPV, race, smoking and parity
  3. In stratified analyses, ORs for other races (Hispanic/Asian/Pacific Islanders/Native Americans) not shown (n = 45)