Fig. 3
Role of NK cells and T lymphocytes in LDV-mediated protection against AB1 growth. a Survival of groups of 7 BALB/c mice either uninfected (open circles) or infected with LDV one day before tumor administration, with (closed squares) or without (closed circles) anti-ASGM1 treatment, was monitored daily after i.p. administration of AB1 cells. b Survival of groups of 6 BALB/cAnNRj-Foxn1 nu/nu mice either uninfected (open circles) or infected with LDV one day before tumor administration (closed circles) was monitored daily after i.p. administration of AB1 cells. c NK cell cytotoxic activity. Cytolysis of CFSE-labeled AB1 or Yac-1 cells (2.5 × 104 cells/ml) was analysed by flow cytometry after 4 h incubation with serial ratios (E:T: effector/target cell ratio) of purified NK cells from control (grey bars) or LDV-infected (black bars) mice. Results are expressed as % of lysed target cells, mean ± SEM for groups of 3 mice. (*p < 0.05; **p < 0.01)