Bio-Specimens | human papillomavirus | Helicobacter pylori | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Participant | Diagnosis at enrolment, specimen collection | Specimen type | Specimen source | Processing | Number specimens available | Number Beta-globin positive | Number HPV DNA positive | Number HPV-16 positive | Prevalence 95% CI | Prevalence HPV-16 95% CI | Other HPV type identified | Number H. pylori ureA positive | Number H. pylori 16 s positive | Number H. pylori ureA/16 s positive | Prevalence 95% CI | Number cagA + H. pylori in ureA/16 s positive specimens | Prevalence cagA+ in ureA/16 s positive specimens 95% |
CASES | 2012 | Tissue, fresh | Endoscopy | DNA/RNA later, frozen at − 80 °C | 62 | 62 | 1 | 1 | 2% (0–9%) | 2% (0–9%) | 30 | 30 | 34 | 55% (42–68%) | 20* | 59% (41–75%) | |
Buccal cells, fixed | Oral wash saline & gargling | Ethanol fixed | 61 | 61 | 7 | 1 | 11% (5–22%) | 2% (0–9%) | HPV-18, HPV-31, HPV-35, HPV-51, HPV-56, HPV-66 | 8 | 3 | 8 | 13% (6–24%) | 2 | 25% (3–65%) | ||
CONTROLS | 2012–2013 | Buccal cells, fixed | Oral wash saline & gargling | Ethanol fixed | 57 | 56 | 4 | 1 | 7% (2–17%) | 2% (0–10%) | HPV-18, HPV-35, HPV-39, HPV-53, HPV-66 | 4 | 3 | 4 | 7% (2–17%) | 2 | 50% (7–93%) |