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Table 2 Comparison of cytokine levels in cervical lesions of different grades

From: The value of cytokine levels in triage and risk prediction for women with persistent high-risk human papilloma virus infection of the cervix

Cytokines

Groups

N

Cytokine levels (pg/mL)

P *

  

IL-6

HPV-negative

29

4.72 (4.22–6.57)

Reference

  

NSIL

43

6.22 (4.46–8.71)

P = 0.150

Reference

 

LSIL

35

16.68 (12.25–26.25)

P = 0.00

P = 0.00

Reference

HSIL

39

38.26 (33.14–48.66)

P = 0.00

P = 0.00

P = 0.00

IL-2

HPV-negative

29

7.89 (7.29–8.38)

Reference

  

NSIL

43

7.47 (6.89–8.24)

P = 0.283

Reference

 

LSIL

35

6.70 (6.34–7.11)

P = 0.00

P = 0.00

Reference

HSIL

39

6.52 (5.89–6.99)

P = 0.00

P = 0.00

P = 0.058

IL-4

HPV-negative

29

5.03 (4.48–5.87)

Reference

  

NSIL

43

5.71 (4.32–7.02)

P = 0.190

Reference

 

LSIL

35

5.06 (4.43–6.07)

P = 0.824

P = 0.197

Reference

HSIL

39

5.27 (4.17–5.83)

P = 0.696

P = 0.153

P = 0.903

IL-10

HPV-negative

29

3.62 (3.24–5.94)

Reference

  

NSIL

43

3.55 (2.94–6.11)

P = 0.663

Reference

 

LSIL

35

5.40 (3.19–6.20)

P = 0.513

P = 0.298

Reference

HSIL

39

5.19 (3.40–5.78)

P = 0.343

0.177

0.961

TNF

HPV-negative

29

4.81 (3.55–5.97)

Reference

  

NSIL

43

4.38 (3.57–6.61)

P = 0.836

Reference

 

LSIL

35

5.52 (3.32–6.72)

P = 0.925

P = 0.916

Reference

HSIL

39

5.07 (3.73–6.38)

P = 0.891

P = 0.666

P = 0.927

IFN-γ

HPV-negative

29

3.91 (3.07–5.94)

Reference

  

NSIL

43

3.24 (2.71–6.11)

P = 0.323

Reference

 

LSIL

35

3.74 (2.93–6.16)

P = 0.903

P = 0.448

Reference

HSIL

39

5.09 (3.17–5.78)

P = 0.780

P = 0.157

P = 0.697

IL-17A

HPV-negative

14

10.86 (9.75–13.60)

Reference

  

NSIL

19

10.74 (9.48–12.15)

P = 0.477

Reference

 

LSIL

18

11.32 (9.60–13.06)

P = 0.849

P = 0.378

Reference

HSIL

18

12.09 (10.51–13.21)

P = 0.424

P = 0.057

P = 0.462

TGF-β

HPV-negative

29

193.82 (155.13–249.52)

Reference

0.40

0.51

NSIL

37

193.8200 (178.95–259.63)

P = 0.329

Reference

 

LSIL

35

200.56 (165.14–267.75)

P = 0.422

P = 0.573

Reference

HSIL

39

202.23 (157.16–288.76)

P = 0.435

P = 0.433

P = 0.685

  1. * The differences in cytokine levels among groups were analyzed by the t-test and Mann–Whitney U test
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Infectious Agents and Cancer

ISSN: 1750-9378

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