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Fig. 1 | Infectious Agents and Cancer

Fig. 1

From: Dissecting the roles of thymoquinone on the prevention and the treatment of hepatocellular carcinoma: an overview on the current state of knowledge

Fig. 1

Key signaling pathways that regulate the function of TQ in HCC develepoment and in the hepatic injury. The cartoon recapitulates the principle signaling pathways by which TQ blocks hepatocellular carcinoma growth (a) and the hepatic injury (b). Abbreviations: GSHPx: glutathione peroxidase; CAT: catalase; GST: glutathione-s-transferase; Ki67: cell proliferating markers(Labeling index); PCNA: proliferating cellular antigen; CDK4: Cyclin-Dependent Kinase 4; NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells; ROS: reactive oxygen species; NQO1: NADFH quinone oxidoreductase 1; HO-1: Heme oxygenase isoenzime-1; TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand; Bcl-2: BCL2, Apoptosis Regulator; Notch1: Neurogenic locus notch homolog protein 1; NICD1: notch intracellular domain 1; BAX: Bcl-2 Associated X, Apoptosis Regulator

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Infectious Agents and Cancer

ISSN: 1750-9378

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