Concordance of oral HPV prevalence between patients with oropharyngeal cancer and their partners

Table 2 Demographic data, exposure, and HPV-related disease history among participants segregated by oral swab status^f

Characteristic	Patients (N = 198)			Partners (N = 198)
Characteristic	Swab positive (N = 28)	Swab negative (N = 170)	p-Value	Swab positive (N = 30)	Swab negative (N = 168)	p-value
Age, years
< 55	12 (42.9 %)	76 (44.7 %)	.86	15 (50 %)	93 (56 %)	.54
≥ 55	16 (57.1 %)	94 (55.3 %)	.86	15 (50 %)	73 (44 %)	.54
Sex
Female	5 (17.9 %)	32 (18.8 %)	1.0	26 (86.7 %)	135 (80.4 %)	.61
Male	23 (82.1 %)	138 (81.2 %)	1.0	4 (13.3 %)	33 (19.6 %)	.61
Race
White	22 (78.6 %)	156 (91.8 %)	.032	23 (76.7 %)	134 (79.8 %)	.70
Other	6 (21.4 %)	14 (8.2 %)	.032	7 (23.3 %)	34 (20.2 %)	.70
Smoking status^a
Former/never	14 (70.0 %)	80 (71.4 %)	.90	13 (61.9 %)	61 (67.8 %)	.61
Current	6 (30 %)	32 (28.6 %)	.90	8 (38.1 %)	29 (32.2 %)	.61
Prior alcohol use^b
None	3 (11.1 %)	15 (8.9 %)	.72	6 (20 %)	34 (21.1 %)	.89
Yes	24 (88.9 %)	154 (91.1 %)	.72	24 (80 %)	127 (78.9 %)	.89
Prior HPV-related disease
None	28 (100.0 %)	157 (93.5 %)	.37	23 (76.7 %)	133 (80.1 %)	.67
Yes	0 (0.0 %)	11 (6.5 %)	.37	7 (23.3 %)	33 (19.9 %)	.67
Prior benign HPV-related disease^c
None	28 (100.0 %)	165 (97.1 %)	1.0	30 (100 %)	161 (95.8 %)	.60
Yes	0 (0.0 %)	5 (2.9 %)	1.0	0 (0 %)	7 (4.2 %)	.60
Prior HPV-related malignancy^d
None	27 (96.4 %)	165 (97.1 %)	1.0	29 (96.7 %)	163 (97 %)	1.0
Yes	1 (3.6 %)	5 (2.9 %)	1.0	1 (3.3 %)	5 (3 %)	1.0
HPV status of oropharyngeal tumor^e
Negative	2 (11.8 %)	14 (11 %)	1.0	2 (10.5 %)	14 (11.2 %)	1.0
Positive	15 (88.2 %)	113 (89 %)	1.0	17 (89.5 %)	111 (88.8 %)	1.0
Oral mouth swab status of matched pair
HPV Negative	9 (32.1 %)	159 (93.5 %)	<.001	11 (36.7 %)	159 (94.6 %)	<.001
HPV Positive	19 (67.9 %)	11 (6.5 %)		19 (63.3 %)	9 (5.4 %)

^a8 swab positive and 58 swab negative patients had missing data on smoking; 1 swab positive and 1 swab negative patient had missing data on prior alcohol use
^b9 swab positive and 78 swab negative partners had missing data on smoking; 7 swab negative partners had missing data on prior alcohol use
^cbenign HPV-related disease defined as CIN I-III, dysplasia
^dCervical cancer, anal cancer, prior HNSCC cancer
^eBy p16 IHC (N = 121) or HPV ISH (N = 104); data were unavailable for 54 patients
^fPercentages are calculated as a column percentage

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